Bupropion attenuates methamphetamine self-administration in adult male rats

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Bupropion attenuates methamphetamine self-administration in adult male rats.

Bupropion is a promising candidate medication for methamphetamine use disorder. As such, we used a preclinical model of drug-taking to determine the effects of bupropion on the reinforcing effects of methamphetamine (0.025, 0.05 or 0.1 mg/kg/infusion). Specificity was determined by investigating the effects of bupropion on responding maintained by sucrose. In the self-administration study, rats...

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ژورنال

عنوان ژورنال: Drug and Alcohol Dependence

سال: 2009

ISSN: 0376-8716

DOI: 10.1016/j.drugalcdep.2008.09.006